Sphingomyelin encrypts tissue factor: ATP-induced activation of A-SMase leads to tissue factor decryption and microvesicle shedding
Abstract: A majority of tissue factor (TF) on cell surfaces exists in an encrypted state with minimal to no procoagulant activity.At present, it is unclear whether limited availability of phosphatidylserine (PS) and/or a specific membrane lipid in the outer leaflet of the plasma membrane contributes to TF encryption.Sphingomyelin (SM) is a major ph