SPHINGOMYELIN ENCRYPTS TISSUE FACTOR: ATP-INDUCED ACTIVATION OF A-SMASE LEADS TO TISSUE FACTOR DECRYPTION AND MICROVESICLE SHEDDING

Sphingomyelin encrypts tissue factor: ATP-induced activation of A-SMase leads to tissue factor decryption and microvesicle shedding

Abstract: A majority of tissue factor (TF) on cell surfaces exists in an encrypted state with minimal to no procoagulant activity.At present, it is unclear whether limited availability of phosphatidylserine (PS) and/or a specific membrane lipid in the outer leaflet of the plasma membrane contributes to TF encryption.Sphingomyelin (SM) is a major ph

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Efficient In Vitro and In Vivo Activity of Glyco-Engineered Plant-Produced Rabies Monoclonal Antibodies E559 and 62-71-3.

Rabies is a neglected zoonotic disease that has no effective treatment after onset of illness.However the 15-eg1053cl disease can be prevented effectively by prompt administration of post exposure prophylaxis which includes administration of passive immunizing antibodies (Rabies Immune Globulin, RIG).Currently, human RIG suffers from many restricti

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The mosquito vectors that sustained malaria transmission during the Magude project despite the combined deployment of indoor residual spraying, insecticide-treated nets and mass-drug administration.

The "Magude project" aimed but failed to interrupt local malaria transmission in Magude district, southern Mozambique, by using a comprehensive package of interventions, including indoor residual spraying (IRS), pyrethroid-only long-lasting insecticide treated nets (LLINs) and mass-drug administration (MDA).Here we present detailed information on t

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